Mukherjee Lab
Glioblastoma Outcomes & Palliative Care Analysis
I collaborated with the Mukherjee Lab to analyze national cancer database data and
evaluate the impact of palliative care and facility characteristics on outcomes for
brain tumor patients. I contributed to data extraction, processing, segmentation,
analytic pipelines, and summary tables that informed our findings.
R Code Repository
Statistical analyses and model logic were organized in R. The local script includes cohort filtering, recoding, descriptive statistics, and tests for group differences.
# Cohort setup citrue <- NCDBMeningioma_1[ NCDBMeningioma_1$PALLIATIVE_CARE == 0, ] pctrue <- NCDBMeningioma_1[ NCDBMeningioma_1$PALLIATIVE_CARE == 4, ] plcrecode <- factor(ifelse( ciandpctrue$PALLIATIVE_CARE == 4, "1", "0")) agep <- wilcox.test( citrue$AGE, pctrue$AGE, exact = FALSE)
Python Project (Data Segmentation)
I also contributed to a Python project structure used for segmentation and inference workflows, with reusable training, evaluation, and inference entry points.
gbm_segmentation_project/ |-- Resources/Toby/ | |-- main.py | |-- train.py | |-- inference.py | |-- train_unetr.py | |-- transformer.py | |-- utils.py | |-- config.py | |-- requirements.txt | |-- combine_views.ipynb | `-- model_train.sh mode = train | evaluate | inference
Key Contributions
- Segmented and cleaned national database records for downstream analysis.
- Built reproducible processing and variable-derivation workflows.
- Performed exploratory analysis to inform downstream modeling.
- Assisted with Kaplan-Meier survival analysis and logistic regression modeling.
- Generated publication-ready tables and figure-ready summaries.
Key Results
KM Curve by Facility Type
Survival differs by facility characteristics after cohort stratification.
KM Curve by Treatment Intent
Treatment intent separates the survival curves strongly across follow-up.
KM Curve for Palliative Care
Palliative-care status was associated with a distinct survival profile.
Baseline Characteristics
| Characteristic | Curative | Palliative | P |
|---|---|---|---|
| Mean Age | 64 +/- 15 | 73 +/- 15 | <0.001 |
| Female | 26.9% | 29.7% | 0.299 |
| White | 87.1% | 82.3% | Ref |
| Black | 12.5% | 10.5% | 0.400 |
Logistic Regression
| Variable | Univariable OR | Multivariable AOR | P |
|---|---|---|---|
| Increasing Age | 1.05 | 1.05 | <0.001 |
| Charlson-Deyo | 2.29 | 1.30 | 0.344 |
| Insurance | 1.14 | 1.73 | 0.447 |
| Facility Type | 2.53 | 5.36 | 0.001 |
Overall Survival
| Variable | Hazard Ratio | P |
|---|---|---|
| Increasing Age | 1.03 [1.03-1.04] | <0.001 |
| Male vs Female | 1.06 [1.04-1.07] | <0.001 |
| Charlson-Deyo | 1.39 [1.30-1.49] | <0.001 |
| Private Insurance | 0.90 [0.86-0.94] | <0.001 |